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王春河

姓 名 王春河 性 别 职 称 研究员
学 历 博士 电 话 021-68077887 传 真
电子邮件 wangc@simm.ac.cn 个人主页 主页链接 专家类别 研究员
职 务 课题组长
通讯地址 上海市蔡伦路720弄张江药谷1号楼342室
个人简介

具有工业界和学术界两方面的抗体药物研发经验。1999年获中国科学院上海药物研究所药理学博士学位,研究生期间主要从事阿片药物成瘾及耐受机制的研究。博士毕业以后在美国俄勒冈健康科学大学(OHSU)完成博士后训练, 随后被聘为助理教授,其团队研发的治疗多发性硬化症的融合蛋白药物RTL已经在美国完成I期临床。2009初加入“世界500强”的美国礼来公司,从事抗体药物分子的靶点发现和抗体筛选工作。2015年回国建设上海药物研究所的抗体药物研发平台,建立了杂交瘤与噬菌体展示技术相结合的抗体药物筛选方法,可以一步实现抗体分子骨架区100%的人源化和亲和力成熟。研发的新一代抗体偶联药物(ADC)连接子技术平台解决了采用高脂溶性载荷的ADC分子的成药性问题,并实现成果转化。作为带头人主持“十三五”国家重大新药创制专项子课题1项,国家自然科学基金面上项目2项,中科院重大科技专项2项。近年来获得4项抗体药物发明专利授权,发表SCI研究论文33篇。入选中组部及中科院“高端人才引进计划”。

 

教育经历:

1.1999.04-2005.03 美国俄勒冈健康科学大学,神经免疫学博士后

2.1994.08-1999.06 中国科学院上海药物研究所,药理学博士

3.1990.09-1994.06  山东大学,微生物学本科 

工作经历
  • 中国科学院上海药物研究所,课题组长、研究员
     
     
     
  • 美国礼来制药公司,生物药物发现研究中心,资深科学家
     
     
     
  • 美国俄勒冈健康科学大学,神经免疫,助理教授
     
     
     
研究方向

1. 单克隆及双特异性抗体药物分子的发现、筛选和工程技术改造

2. 新型抗体化学药物偶联体(ADC)药物的连接子改造

科研项目
    1.国家“十三五”重大新药创制科技专项,448万,子课题负责人
    2.国家自然科学基金面上项目,57万,课题负责人
    3.国家自然科学基金面上项目,54万,课题负责人
    4.中科院战略性先导科技专项,400万元, 子课题负责人
    5.中科院战略性先导科技专项,100万元, 子课题负责人
    6.中科院药物创新研究院自主部署项目生物药专项,100万元,子课题负责人 
科研成果
1.建立了杂交瘤与噬菌体展示技术相结合的抗体药物筛选方法;
2.新一代抗体偶联药物(ADC)连接子技术平台解决了采用高脂溶性载荷的ADC分子的成药性问题,并实现成果转化;
3.多个分子进入工艺研发及临床前研究阶段。
荣誉获奖
    1.中国科学院院长奖学金一等奖
    2.中国科学院地奥奖学金一等奖
    3.中国科学院伟华奖学金一等奖
    4.美国多发性硬化症学会新药研发领航员奖
    5.约翰. 惠特克多发性硬化症青年研究学者奖
    6.约翰.惠特克多发性硬化症青年研究学者奖
     
代表论著

    1.Dong, X, Li H, Pei M, Tan J, Chen G, Li S, Xie Z, Wang Q, Wang G, Chen Y, Wang C. 2022. Analgesic effects of nerve growth factor-directed monoclonal antibody on diabetic neuralgia in an animal model. FEBS Open Bio. doi:10.1002/2211-5463.13410. 

    2.Liu X, Zhou T, Wang Y, Pei M, Chen YL, Wang G, Chu W, Wang Q, Wang C. 2022. TROP2 as patient-tailoring but not prognostic biomarker for breast cancer. OncoTargets and Therapy. 15: 509–520. 

    3.Liang Z, Tan J, Xie Z, Chen G, Liu G, Lin Yuan, Wang K, Ding H, Qiu H, Wang C. 2022. Chemotherapy-induced peripheral neuropathy is alleviated by NGF monoclonal antibody. Acta Pharmacol Sin 0:1-7. 

    4.Chu W, Xu H, Wang Y, Xie Y, Chen YL, Tan X, Huang C, Wang G, Wang Q, Luo W, Xia N, Geng M, Xie Z, Wang C. 2022. HER2/PD-1 bispecific antibody in IgG4 subclass with superior antitumor activities. Clinical and Translational Medicine 12:e791.

    5.Mu S, Liang Z, Wang1 Y, Chu1 W, Chen Y, Wang Q, Wang G, Wang C. 2022. PD-L1/TIGIT bispecific antibody showed survival advantage in animal model. Clinical and Translational Medicine. 12:e754. 

    6.Ou J, Zhang Y, Wang Y, Zhang Z, Wei H, Yu J, Wang Q, Wang G, Zhang B, Wang C. 2022. ACE2-targeting antibody suppresses sars-cov-2 omicron and delta variants. Signal Transduction and Targeted Therapy.7:43.

    7.Dai X, Wang Y, Li X, Pei M, Dong X, Gold BG, Zhong Y,Vandenbark, AA, Neve KA, Offner H, Wang G, Wang C. 2022. Tyrphostin A9 protects axons in experimental autoimmune encephalomyelitis through activation of ERKs. Life Science, 94:120383.

    8.Chen YL, Cui Y, Liu X, Liu G, Dong X, Tang L, Hung Y, Wang C, Feng MQ. 2022. Bispecific antibody targeting her2 and pd-l1 inhibits tumor growth with superior efficacy. J Biol Chem. 297:101420 

    9.Pei M., Liu T, Ouyang L, Sun J, Deng X, Sun X, Wu W, Huang P, Chen Y, Tan X, Liu X, Zhu P, Liu Y, Wang D, Wu J, Wang Q, Wang G, Gong L, Qin Q, Wang C. 2021. Enzyme-linked immunosorbent assays for quantification of mmae-conjugated ADCs and total antibodies in cynomolgus monkey sera. Journal of Pharmaceutical Analysis. https://www.sciencedirect.com/ science/ article/ pii/ S2095177921001350.

    10.Chen, Y., Zhang, YN., Yan, R. Wang, G., Zhang Y., Zhang Z.R., Li Y, Ou J., Chu, W., Liang Z., Wang Y., Chen Y.L., Chen G., Wang Q., Zhou Q., Zhang B., Wang C. 2021. ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker. Signal Transduction and Targeted Therapy. 6, 315. 

    11.Shao, T., Chen T., Chen, Y., Liu, X., Chen, Y.L., Wang, Q., Wang C. 2020. Construction of paclitaxel-based antibody drug conjugate with pegylated linker to achieve superior therapeutic index. Signal Transduction and Targeted Therapy. 15:132.

    12.王春河、万亚坤、黄鹏、李佳。生物技术药物兴起与展望。《现代药物研发回顾与展望--新药研发何去何从》,白东鲁、沈竞康编,化工出版社 2019。 

    13.Bodhankar, S., Wang, C., Vandenbark, A.A., and Offner, H. 2011. Estrogen-induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence of B cells. Eur. J. Immunol. 41:1165

    14.Wang, C., Li, Y., Proctor, T. M., Vandenbark, A. A. and Offner, H. 2010. Down-modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis. J. Neurosci. Res. 88:7.

    15.Wang, C., Dehghani, B., Li, Y., Kaler, L. J., Vandenbark, A. A., and Offner, H., 2009. Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin-17 production via programmed death 1. Immunology 126:329.

    16.Wang, C., Dehghani, B., Li, Y., Kaler, L. J., Proctor, T., Vandenbark, A. A. and Offner, H. 2009. Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1. J. Immunol. 182:3294.

    17.Offner, H., Sinha, S., Wang, C., Burrows, G. G., and Vandenbark. A. A., 2008. Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis. Rev. Neurosci. 19:327.

    18.Wang, C., Dehghani, B., Magrisso, I. J., Rick, E. A., Bonhomme, E., Cody, D. B., Elenich, L. A., Subramanian, S., Murphy, S. J., Kelly, M. J., Rosenbaum, J. S., Vandenbark, A. A. and Offner, H. 2008. GPR30 contributes to estrogen-induced thymic atrophy. Mol. Endocrinol. 22:636.

    19.Wang, C., Gold, B.G., Kaler, L.J., Yu, X., Afentoulis, M.E., Burrows G.G., Vandenbark, A.A., Bourdette, D.N., Offner, H. 2006. Antigen-specific therapy promotes repair of myelin and axonal damage in established EAE. J. Neurochem. 98: 1816.

    20.Wang, C., Chou, Y. C., Rich, C. M., Link, J.M., Afentoulisa, M. E., van Noort, J. M., Wawrousekd, E. F., Offner, H., Vandenbarka, A. A. 2006. B-crystallin-reactive T cells from knockout mice are not encephalitogenic. J. Neruoimmunol. 176: 51.

    21.Offner, H., Subramanian, S., Parker, S.M., Wang, C., Afentoulis, M. E., Lewis, A., Vandenbark, A. A. and Hurn, P. D. 2006. Splenic atrophy in experimental stroke is accompanied by increased Treg cells and circulating macrophages. J. Immunol. 176: 6523.

    22.Offner, H., Subramanian, S., Wang, C., Afentoulis, M. E., Vandenbark, A. A., Huan, J., and Burrows, G. G. 2005. Treatment of passive EAE in SJL mice with a recombinant TCR ligand induces high levels of IL-13. J.Immunol. 175: 4103.

    23.Wang, C., Buck, D. C., Yang, R, Macey, T. A., and Neve, K. A. 2005. Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases. J.Neurochem. 93: 899.

    24.Chou, Y. K., Burrows, G. G., LaTocha, D., Wang, C., Subramanian, S., Bourdette, D. N., and Vandenbark, A. A. 2004. CD4 T-cell epitopes of human alpha B-crystallin. J.Neurosci.Res. 75: 516.

    25.Wang, C., Mooney, J. L., Meza-Romero, R., Chou, Y. K., Huan, J., Vandenbark, A. A., Offner, H., and Burrows, G. G. 2003. Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation. J.Immunol. 171: 1934.

    26.Vandenbark, A. A., Rich, C., Mooney, J., Zamora, A., Wang, C., Huan, J., Fugger, L., Offner, H., Jones, R., and Burrows, G. G. 2003. Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice. J.Immunol. 171: 127.

    27.Burrows G. G., Chou Y. K., Wang C, Chang J. W., Finn T. P., Culbertson N. E., Kim J, Bourdette D. N., Lewinsohn D. A., Lewinsohn D. M., Ikeda M, Yoshioka T, Allen C. N., Offner H, Vandenbark A. A. 2001. Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells. J Immunol 167: 4386.

    28.Wang C, Zhou D. H., Chen J, Chi Z. Q. 1999. Leucine-2-alanine enkephalin induced delta opioid receptors internalization expressed stably in CHO cells. Acta Pharmacol Sin. 20: 491.

    29.Wang C, Zhou D. H., Chen Z. J., Wei Q, Chen J, Li G. F., Pei G, Chi Z. Q. 1998. The C-truncated delta-opioid receptor underwent agonist-dependent activation and desensitization. Biochem Biophys Res Commun 249: 321.

    30.Wang C, Zhou D. H., Chen J, Li G. F., Pei G., Chi Z. Q. 1997. Binding properties of C-truncated delta opioid receptors. Acta Pharmacol Sin 18: 337.

    31.Wei Q, Zhou D. H., Shen Q. X., Wang C, Pei G, Chi Z. Q. 1998. Human mu-opioid receptor overexpressed in baculovirus system and its pharmacological characterizations. Acta Pharmacol Sin 19: 218.

    32.Zhu X. L., Wang C, Chen Z. J., Wu Y. L., Zhou D. H., Pei G. 1997. The carboxyl terminus mouse delta-opioid receptor is not required for agonist-dependent activation. Biochem Biophys Res Commun 232: 513.

     
社会任职

1.美国免疫学学会会员;
2.达石药业(广东)有限公司创始人、董事长

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