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天然药物化学研究室
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岳建民研究组
叶 阳研究组
赵维民研究组
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 您现在的位置:首页 > 机构设置 > 研究机构 > 研究室 > 天然药物化学研究室 > 岳建民研究组
岳建民研究组
岳建民课题组

  

  课题组现有研究员2名(岳建民、张华),其它副高级人员2名、研究助理1名。

  

  

  主要从事具有重要生物活性天然先导结构的发现与研究。内容包括新颖结构活性天然化合物的发现、结构优化和构效关系研究、新药研究与开发。

 

  (2009.1.1-)

  1. Xing Yan, Yun Fan, Wei Wei, Pingping Wang, Qunfang Liu, Yongjun Wei, Lei Zhang, Guoping Zhao*, Jianmin Yue*, Zhihua Zhou*, Production of bioactive ginsenoside compound K in metabolically engineered yeast, Cell Research, 2014, 24, 770-773.


  2. Jin-Biao Xu, Hua Zhang, Li-She Gan, Ying-Shan Han, Mark A Wainberg, and Jian-Min Yue*, Logeracemin A, an Anti-HIV Daphniphyllum Alkaloid Dimer with a New Carbon Skeleton from Daphniphyllum longeracemosum, Journal of the American Chemical Society, 2014, 136(21), 7631-7633.  


  3. Yao Wang, Quan-Fang Liu, Ji-Jun Xue, Yu Zhou, Huang-Chao Yu, Sheng-Ping Yang, Bo Zhang, Jian-Ping Zuo, Ying Li*, and Jian-Min Yue*,Ivorenolide B, an Immunosuppressive 17-Membered Macrolide from Khaya ivorensis: Structural Determination and Total Synthesis, Organic Letters, 2014, 16 (7), 2062-2065.  


  4. Jia Liu, Xiu-Feng He,Gai-Hong Wang, Emilio F. Merino, Sheng-Ping Yang, Rong-Xiu Zhu, Li-She Gan, Hua Zhang, Maria B. Cassera, He-Yao Wang, David G. I. Kingston, and Jian-Min Yue*, Aphadilactones A−D, Four Diterpenoid Dimers with DGAT Inhibitory and Antimalarial Activities from a Meliaceae Plant,The J. of Organic Chemistry, 2014, 79(1), 599-607.  


  5. Hua Zhang, Hong-Bing Liu, and Jian-Min Yue*, Organic Carbonates from Natural Sources, Chemical Reviews, 2014, 114 (1), 883-898. 


  6. Guo-Cai Wang, Hua Zhang, Hong-Bing Liu, Jian-Min Yue*, Laevinoids A and B: Two Diterpenoids with an Unprecedented Backbone from Croton laevigatus, Organic Letters, 2013, 15(18), 4880-4883.  


  7. Hua Zhang, Chuan-Rui Zhang, Kong-Kai Zhu, An-Hui Gao, Cheng Luo, Jia Li, and Jian-Min Yue*, Fluevirosines AC: a Biogenesis Inspired Example in the Discovery of New Bioactive Scaffolds from Natural Sources, Organic Letters, 2013, 15 (1), 120-123.  


  8. Bo Zhang, Yao Wang, Sheng-Ping Yang, Yu Zhou, Wen-Bin Wu, Tang Wei, Jian-Ping Zuo, Ying Li* and Jian-Min Yue*, Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis, Journal of the American Chemical Society 2012, 134(51), 20605-20608. 


  9. Sheng-Ping Yang, Xiao-Wei Zhang, Jing Ai, Jin-Biao Xu, Bo Zhang, Zu-Shang Su, Ying Wang, Lu Wang, Jian Ding, Mei-Yu Geng*, and Jian-Min Yue,* Potent HGF/c-Met Axis Inhibitors from Eucalyptus globules: the Coupling of Phloroglucinol and Sesquiterpenoid Is Essential for the Activity,Journal of Medicinal Chemistry, 2012, 55(18), 8183-8187.


  10. Hong-Bing Liu, Hua Zhang, Ping Li, Zhao-Bing Gao, and Jian-Min Yue*, Chukrasones A and B: Potential Kv1.2 Potassium Channel Blockers with New Skeletons from Chukrasia tabularis, Organic Letters, 2012, 14(17), 4438-4441.  


  11. Tao Yuan, Rong-Xiu Zhu, Sheng-Ping Yang, Hua Zhang, Chuan-Rui Zhang, Jian-Min Yue*, Serratustones A and B Representing an Unprecedented Dimerization Pattern of Two Types of Sesquiterpenoids from Chloranthus serratus, Organic Letters, 2012, 14(12), 3198-3201. 


  12. Mei-Ling Han, Hua Zhang, Sheng-Ping Yang and Jian-Min Yue*, Absolute Structures of Walsucochinoids A and B: Novel Rearranged Limonoids from Walsura cochinchinensis, Organic Letters, 2012, 14(2), 486-489. 


  13. Chuan-Rui Zhang, Cheng-Qi Fan, Shi-Hui Dong, Hong-Bing Liu, Wen-Bin Zhou, Yan Wu, and Jian-Min Yue*, Angustimine and Angusti
folimine: Two New Alkaloids from Daphniphyllum angustifolium, Organic Letters, 2011, 13(9), 2440-2443.


 

  14. Sheng-Ping Yang, Hua-Dong Chen, Shang-Gao Liao, Bo-Jun Xie, Ze-Hong Miao, and Jian-Min Yue*, Aphanamolide A, a New Limonoid from Aphanamixis polystachya, Organic Letters, 2011, 13(1), 150-153. 


  15. Hua-Dong Chen, Sheng-Ping Yang, Xiu-Feng He, Jing Ai, Zhen-Kai Liu, Hong-Bing Liu, Mei-Yu Geng, and Jian-Min Yue*, Trigochinins AC: Three Novel Daphnane-type Diterpenes from Trigonostemon chinensis, Organic Letters 2010, 12(6), 1168-1171. 


  16. Tao Yuan, Rong-Xiu Zhu, Sheng-Ping Yang, Shang-Gao Liao and Jian-Min Yue,Structure Determination of Grandifotane A from Khaya grandifoliola by NMR, X-Ray Diffraction, and ECD Calculation, Organic Letters, 2010, 12(2), 252-255. 


  17. Shang-Gao Liao, Hua-Dong Chen and Jian-Min Yue*,Plant Orthoesters, Chemical Reviews, 2009, 109(3), 1092-1140. 


  18. Chuan-Rui Zhang, Hong-Bing Liu, Shi-Hui Dong, Jian-Yong Zhu, Yan Wu, and Jian-Min Yue*, Calycinumines A and B, two novel alkaloids from Daphniphyllum calycinum, Organic Letters, 2009, 11(20), 4692-4695. 


  19. Hua-Dong Chen, Xiu-Feng He, Jing Ai, Mei-Yu Geng and Jian-Min Yue*, Trigochilides A and B, Two Highly Modified Daphnane-Type Diterpenoids from Trigonostemon chinensis, Organic Letters, 2009, 11(18), 4080-4083.


  20. Tao Yuan, Sheng-Ping Yang, Chuan-Rui Zhang, Sheng Zhang, and Jian-Min Yue*, Two Limonoids, Khayalenoids A and B with an Unprecedented 8-Oxa-tricyclo[4.3.2.02,7] undecane Motif from Khaya senegalensis, Organic Letters, 2009, 11(3), 617-620. 


   

  

  课题组拥有Buchi旋转蒸发仪16台,自动收集仪4台,制备型HPLC仪7台(Waters 2545、Varian Sd-1)和分析型HPLC仪1台(Agilent 1100 Series),Flash中压柱层析系统1套(Agela),Shimadzu UV-2550 UV、电子分析天平等。

  

  

 
课题组部分成员   waters 2545 HPLC

  
研究室组织结构

 
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